Dr. Ahmed will attend the CSU Maker Convening 2018 at SSU. Let’s see if we can get some maker space going at CSUF!
Congrats to Paris for being admitted to pursue his Ph.D. at Princeton University!
Congrats on being admitted to the MIT Department of Physics!!
Have a great research trip this summer in Grenoble, France! Paris will be working at the Institut Néel on strain-mediated coupling of a quantum-dot mechanical oscillator hybrid system, and Monika will be working at the Université Grenoble Alpes on mechanical waves in epithelial cell sheets.
image from FIFA.com
Congratulations on being accepted to the Princeton Summer School on the Physics of Life! It’s going to be a blast!!
image from states.jsa.org
We have a new paper that just appeared online!
Active diffusion of intracellular components is emerging as an important process in cell biology. This process is mediated by complex assemblies of molecular motors and cytoskeletal filaments that drive force generation in the cytoplasm and facilitate enhanced motion. The kinetics of molecular motors have been precisely characterized in vitro by single molecule approaches, but their in vivo behavior remains elusive. Here, we study the active diffusion of vesicles in mouse oocytes, where this process plays a key role in nuclear positioning during development, and combine an experimental and theoretical framework to extract molecular-scale force kinetics (force, power stroke, and velocity) of the in vivo active process. Assuming a single dominant process, we find that the nonequilibrium activity induces rapid kicks of duration τ ∼ 300 μs resulting in an average force of F ∼ 0.4 pN on vesicles in in vivo oocytes, remarkably similar to the kinetics of in vitro myosin-V. Our results reveal that measuring in vivo active fluctuations allows extraction of the molecular-scale activity in agreement with single-molecule studies and demonstrates a mesoscopic framework to access force kinetics.
Congrats to Corbyn, Hunter, and Mauricio for all receiving the Dan Black Fellowship!